Liver metastases inhibit immunotherapy efficacy
KE Lindblad, A Lujambio - Nature medicine, 2021 - nature.com
Nature medicine, 2021•nature.com
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Liver metastases lead to resistance to immunotherapy through the ‘siphoning’ of tumor antigen–specific CD8+ T cells into the liver, which results in a systemic ‘immune desert’ incapable of controlling tumor burden.
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