An elaborate volume regulation system based on interplay of ion channels and transporters
was evolved to cope with constant osmotic challenges caused by intensive metabolism,
transport and other physiological/pathophysiological events. In animal cells, two types of
anion channels are directly activated by cell swelling and involved in the regulatory volume
decrease (RVD): volume-sensitive outwardly rectifying anion channel (VSOR), also called
volume-regulated anion channel (VRAC), and Maxi-Cl which is the most major type of maxi …