[HTML][HTML] Spatio-temporal aspects, pathways and actions of Ca2+ in surfactant secreting pulmonary alveolar type II pneumocytes
The type II cell of the pulmonary alveolus is a polarized epithelial cell that secretes surfactant
into the alveolar space by regulated exocytosis of lamellar bodies (LBs). This process
consists of multiple sequential steps and is correlated to elevations of the cytoplasmic Ca2+
concentration ([Ca2+] c) required for extended periods of secretory activity. Both chemical
(purinergic) and mechanical (cell stretch or exposure to an air–liquid interface) stimuli give
rise to complex Ca2+ signals (such as Ca2+ peaks, spikes and plateaus) that differ in shape …
into the alveolar space by regulated exocytosis of lamellar bodies (LBs). This process
consists of multiple sequential steps and is correlated to elevations of the cytoplasmic Ca2+
concentration ([Ca2+] c) required for extended periods of secretory activity. Both chemical
(purinergic) and mechanical (cell stretch or exposure to an air–liquid interface) stimuli give
rise to complex Ca2+ signals (such as Ca2+ peaks, spikes and plateaus) that differ in shape …
