Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling
B Chen, M Wang, J Qiu, K Liao, W Zhang, Q Lv… - Journal of Experimental …, 2022 - Springer
Background Abnormal proliferation and migration of cells are hallmarks of cancer initiation
and malignancy. Asparagine endopeptidase (AEP) has specific substrate cleavage ability
and plays a pro-cancer role in a variety of cancers. However, the underlying mechanism of
AEP in cancer proliferation and migration still remains unclear. Methods Co-
immunoprecipitation and following mass spectrometry were used to identify the substrate of
AEP. Western blotting was applied to measure the expression of proteins. Single …
and malignancy. Asparagine endopeptidase (AEP) has specific substrate cleavage ability
and plays a pro-cancer role in a variety of cancers. However, the underlying mechanism of
AEP in cancer proliferation and migration still remains unclear. Methods Co-
immunoprecipitation and following mass spectrometry were used to identify the substrate of
AEP. Western blotting was applied to measure the expression of proteins. Single …
Correction: Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling
B Chen, M Wang, J Qiu, K Liao, W Zhang, Q Lv… - Journal of Experimental …, 2022 - Springer
Tmod3 is highly expressed in many solid tumors and is associated with poor patient
prognosis. A, B snRNA-seq with GBM cells (A) and scRNA-seq with cervical cancer cells (B)
populations colored by clusters, number of cells analyzed in each cluster in the legend and
the expression of Tmod3 in each cluster. The darker the red color, the higher the expression
of the corresponding gene in that cell. C Representative images of low, moderate and high
IHC staining of Tmod3 in glioma tissue array. Scale bar, 40 μm. D Histochemistry score (H …
prognosis. A, B snRNA-seq with GBM cells (A) and scRNA-seq with cervical cancer cells (B)
populations colored by clusters, number of cells analyzed in each cluster in the legend and
the expression of Tmod3 in each cluster. The darker the red color, the higher the expression
of the corresponding gene in that cell. C Representative images of low, moderate and high
IHC staining of Tmod3 in glioma tissue array. Scale bar, 40 μm. D Histochemistry score (H …
