[HTML][HTML] PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post …
BM Steiglitz, DR Keene, DS Greenspan - Journal of Biological Chemistry, 2002 - ASBMB
The procollagen COOH-terminal proteinase enhancer (PCPE) is a glycoprotein that binds
the COOH-terminal propeptide of type I procollagen and potentiates its cleavage by
procollagen C-proteinases, such as bone morphogenetic protein-1 (BMP-1). Recently,
sequencing of a human expressed sequence tag, which maps near the primary open angle
glaucoma region on chromosome 3q21, showed it to encode a novel protein with only 43%
identity with PCPE but with a similar domain structure. Here we show this novel protein to be …
the COOH-terminal propeptide of type I procollagen and potentiates its cleavage by
procollagen C-proteinases, such as bone morphogenetic protein-1 (BMP-1). Recently,
sequencing of a human expressed sequence tag, which maps near the primary open angle
glaucoma region on chromosome 3q21, showed it to encode a novel protein with only 43%
identity with PCPE but with a similar domain structure. Here we show this novel protein to be …