Disabling Gβγ-SNAP-25 interaction in gene-targeted mice results in enhancement of long-term potentiation at Schaffer collateral-CA1 synapses in the hippocampus
Abstract Three SNARE proteins, SNAP-25, syntaxin 1A, and VAMP2 or synaptobrevin 2,
constitute the minimal functional machinery needed for the regulated secretion of
neurotransmitters. Dynamic changes in the regulated release of neurotransmitters are
associated with the induction of long-term plasticity at central synapses. In-vitro studies have
validated the C-terminus of SNAP-25 as a target for inhibitory G i/o-coupled G-protein
coupled receptors at a number of synapses. The physiological consequences of the …
constitute the minimal functional machinery needed for the regulated secretion of
neurotransmitters. Dynamic changes in the regulated release of neurotransmitters are
associated with the induction of long-term plasticity at central synapses. In-vitro studies have
validated the C-terminus of SNAP-25 as a target for inhibitory G i/o-coupled G-protein
coupled receptors at a number of synapses. The physiological consequences of the …