Importance Recurrent and/or metastatic head and neck cancer is usually incurable.
Implementation of precision oncology for these patients has been limited by incomplete
understanding of the molecular alterations underlying advanced disease. At the same time,
the molecular profiles of many rare head and neck cancer types are unknown. These
significant gaps in knowledge need to be addressed to rationally devise new therapies.
Objective To illuminate the distinct biology of recurrent and metastatic head and neck …