[PDF][PDF] Randomized trial of postoperative reirradiation combined with chemotherapy after salvage surgery compared with salvage surgery alone in head and neck …
F Janot, D de Raucourt, E Benhamou, C Ferron… - J Clin …, 2008 - researchgate.net
F Janot, D de Raucourt, E Benhamou, C Ferron, G Dolivet, RJ Bensadoun, M Hamoir…
J Clin Oncol, 2008•researchgate.netResults Sixty-five patients were randomly assigned to each arm. There was no imbalance in
the distribution of the main tumor and patients characteristics. The most serious acute toxicity
in the RT arm was mucositis, attaining grade 3 or 4 in 28% of patients. At 2 years, 39% of
patients in the RT arm and 10% in the WS arm experienced grade 3 or 4 late toxicity
according to Radiation Therapy Oncology Group criteria (P. 06). Disease-free survival (DFS)
was significantly improved in the RT arm, with a hazard ratio of 1.68 (95% CI, 1.13 to 2.50; P …
the distribution of the main tumor and patients characteristics. The most serious acute toxicity
in the RT arm was mucositis, attaining grade 3 or 4 in 28% of patients. At 2 years, 39% of
patients in the RT arm and 10% in the WS arm experienced grade 3 or 4 late toxicity
according to Radiation Therapy Oncology Group criteria (P. 06). Disease-free survival (DFS)
was significantly improved in the RT arm, with a hazard ratio of 1.68 (95% CI, 1.13 to 2.50; P …
Results
Sixty-five patients were randomly assigned to each arm. There was no imbalance in the distribution of the main tumor and patients characteristics. The most serious acute toxicity in the RT arm was mucositis, attaining grade 3 or 4 in 28% of patients. At 2 years, 39% of patients in the RT arm and 10% in the WS arm experienced grade 3 or 4 late toxicity according to Radiation Therapy Oncology Group criteria (P. 06). Disease-free survival (DFS) was significantly improved in the RT arm, with a hazard ratio of 1.68 (95% CI, 1.13 to 2.50; P. 01), but overall survival (OS) was not statistically different.
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