Metabolic syndrome is a multifactorial process induced by a combination of genetic and
environmental factors and recent evidence has highlighted that circadian disruption and
sleep loss contribute to disease pathogenesis. Emerging work in experimental genetic
models has provided insight into the mechanistic basis for clock disruption in disease.
Indeed, disruption of the clock system perturbs both neuroendocrine pathways within the
hypothalamus important in feeding and energetics, in addition to peripheral tissues involved …