Lipid-free apolipoprotein (apo) AI is converted into alpha-migrating high density lipoproteins by lipoprotein-depleted plasma of normolipidemic donors and apo AI …
A von Eckardstein, Y Huang, JJP Kastelein, J Geisel… - Atherosclerosis, 1998 - Elsevier
Plasma of patients with Tangier disease (TD) is devoid of α-LpA-I (apolipoprotein AI-
containing lipoprotein), which in normolipidemic plasma constitutes the majority of high
density lipoprotein (HDL). The residual amounts of apolipoprotein AI (apo AI) in TD plasma
have electrophoretic preβ1-LpA-I mobility. We have previously demonstrated that TD plasma
does not convert preβ1-LpA-I into α-LpA-I. In this study we found that plasmas of
normolipidemic controls, apo AI-deficient patients and patients with fish-eye disease, but not …
containing lipoprotein), which in normolipidemic plasma constitutes the majority of high
density lipoprotein (HDL). The residual amounts of apolipoprotein AI (apo AI) in TD plasma
have electrophoretic preβ1-LpA-I mobility. We have previously demonstrated that TD plasma
does not convert preβ1-LpA-I into α-LpA-I. In this study we found that plasmas of
normolipidemic controls, apo AI-deficient patients and patients with fish-eye disease, but not …
