The identification of the component in the inner membrane of brown adipose tissue mitochondria responsible for regulating energy dissipation
DG Nicholls, VSM Bernson, GM Heaton - … of a Symposium held at Geneva …, 1978 - Springer
DG Nicholls, VSM Bernson, GM Heaton
Effectors of Thermogenesis: Proceedings of a Symposium held at Geneva …, 1978•SpringerThe proton conductance of the inner membrane of hamster brown adipose tissue
mitochondria can be regulated in vitro by exogenous purine nucleotides, which “bind to a
component on the outer face of the inner membrane. This unique mechanism has been
proposed to represent the molecular site of non-shivering thermogenesis in this tissue.
Using a photo-affinity analogue of ATP, we have identified the nucleotide binding
component as a protein of 32,000 daltons.
mitochondria can be regulated in vitro by exogenous purine nucleotides, which “bind to a
component on the outer face of the inner membrane. This unique mechanism has been
proposed to represent the molecular site of non-shivering thermogenesis in this tissue.
Using a photo-affinity analogue of ATP, we have identified the nucleotide binding
component as a protein of 32,000 daltons.
Abstract
The proton conductance of the inner membrane of hamster brown adipose tissue mitochondria can be regulated in vitro by exogenous purine nucleotides, which “bind to a component on the outer face of the inner membrane. This unique mechanism has been proposed to represent the molecular site of non-shivering thermogenesis in this tissue. Using a photo-affinity analogue of ATP, we have identified the nucleotide binding component as a protein of 32,000 daltons.
Springer
