Mitochondrial elongation during autophagy: a stereotypical response to survive in difficult times
LC Gomes, L Scorrano - Autophagy, 2011 - Taylor & Francis
LC Gomes, L Scorrano
Autophagy, 2011•Taylor & FrancisMitochondrial morphological and structural changes play a role in several cellular
processes, including apoptosis. We recently reported that mitochondrial elongation is also
critical to sustain cell viability during macroautophagy. During macroautophagy unopposed
mitochondrial fusion leads to organelle elongation both in vitro and in vivo. Longer
mitochondria are protected from being degraded and possess more cristae where activity of
the ATP synthase is increased, optimizing ATP production in times of nutrient restriction.
processes, including apoptosis. We recently reported that mitochondrial elongation is also
critical to sustain cell viability during macroautophagy. During macroautophagy unopposed
mitochondrial fusion leads to organelle elongation both in vitro and in vivo. Longer
mitochondria are protected from being degraded and possess more cristae where activity of
the ATP synthase is increased, optimizing ATP production in times of nutrient restriction.
Mitochondrial morphological and structural changes play a role in several cellular processes, including apoptosis. We recently reported that mitochondrial elongation is also critical to sustain cell viability during macroautophagy. During macroautophagy unopposed mitochondrial fusion leads to organelle elongation both in vitro and in vivo. Longer mitochondria are protected from being degraded and possess more cristae where activity of the ATP synthase is increased, optimizing ATP production in times of nutrient restriction.
Taylor & Francis Online