[HTML][HTML] RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G2/M checkpoint control
J Xiao, CC Liu, PL Chen, WH Lee - Journal of Biological Chemistry, 2001 - ASBMB
Rad50, an structural maintenance of chromosomes (SMC) protein family member,
participates in a variety of cellular processes, including DNA double-strand break repair, cell
cycle checkpoint activation, telomere maintenance, and meiosis. Disruption of Rad50 in
mice leads to lethality during early embryogenesis, indicating its essential function in normal
proliferating cells. In addition to its ability to form a complex with the DNA double-strand
break repair proteins Mre11 and NBS1, Rad50 may interact with other cellular proteins to …
participates in a variety of cellular processes, including DNA double-strand break repair, cell
cycle checkpoint activation, telomere maintenance, and meiosis. Disruption of Rad50 in
mice leads to lethality during early embryogenesis, indicating its essential function in normal
proliferating cells. In addition to its ability to form a complex with the DNA double-strand
break repair proteins Mre11 and NBS1, Rad50 may interact with other cellular proteins to …