[HTML][HTML] Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signaling-selective …
S Nagai, M Okazaki, H Segawa, C Bergwitz… - Journal of biological …, 2011 - ASBMB
The parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor (PTHR1) in cells of
the renal proximal tubule mediates the reduction in membrane expression of the sodium-
dependent P i co-transporters, NPT2a and NPT2c, and thus suppresses the re-uptake of P i
from the filtrate. In most cell types, the liganded PTHR1 activates Gα S/adenylyl
cyclase/cAMP/PKA (cAMP/PKA) and Gα q/11/phospholipase C/phosphatidylinositol 1, 4, 5-
trisphosphate (IP 3)/Ca 2+/PKC (IP 3/PKC) signaling pathways, but the relative roles of each …
the renal proximal tubule mediates the reduction in membrane expression of the sodium-
dependent P i co-transporters, NPT2a and NPT2c, and thus suppresses the re-uptake of P i
from the filtrate. In most cell types, the liganded PTHR1 activates Gα S/adenylyl
cyclase/cAMP/PKA (cAMP/PKA) and Gα q/11/phospholipase C/phosphatidylinositol 1, 4, 5-
trisphosphate (IP 3)/Ca 2+/PKC (IP 3/PKC) signaling pathways, but the relative roles of each …