Infundibular neurons of the human hypothalamus simultaneously reactive with antisera against endorphins, ACTH, MSH and β-LPH
C Bugnon, B Bloch, D Lenys, D Fellmann - Cell and Tissue Research, 1979 - Springer
C Bugnon, B Bloch, D Lenys, D Fellmann
Cell and Tissue Research, 1979•SpringerIn man, discrete neurons of the infundibular (arcuate) nucleus contain compounds that can
be stained with anti-endorphin (α and β), anti-ACTH, anti-MSH (α and β) and anti-β-LPH
immune sera (IS) In the fetus, certain neurons stain with anti-β-endorphin or anti (17–39)
ACTH starting from the 11th week of fetal life. At the ultrastructural level, these neurons
contain elementary granules that are immunoreactive with anti-βendorphin. In the adult,
neurons immunoreactive with anti-β-endorphin are found in the infundibular nucleus. Their …
be stained with anti-endorphin (α and β), anti-ACTH, anti-MSH (α and β) and anti-β-LPH
immune sera (IS) In the fetus, certain neurons stain with anti-β-endorphin or anti (17–39)
ACTH starting from the 11th week of fetal life. At the ultrastructural level, these neurons
contain elementary granules that are immunoreactive with anti-βendorphin. In the adult,
neurons immunoreactive with anti-β-endorphin are found in the infundibular nucleus. Their …
Summary
In man, discrete neurons of the infundibular (arcuate) nucleus contain compounds that can be stained with anti-endorphin (α and β), anti-ACTH, anti-MSH (α and β) and anti-β-LPH immune sera (I.S.)
In the fetus, certain neurons stain with anti-β-endorphin or anti (17–39)ACTH starting from the 11th week of fetal life. At the ultrastructural level, these neurons contain elementary granules that are immunoreactive with anti-βendorphin.
In the adult, neurons immunoreactive with anti-β-endorphin are found in the infundibular nucleus. Their axonal fibers terminate around blood vessels in the neurovascular zone and in the pituitary stalk, or establish contacts with nonimmunoreactive perikarya of the infundibular nucleus. These neurons can be stained with anti(17–39)ACTH and anti-β-endorphin I.S. The most reactive are also stained moderately with anti-α-MSH, anti-β-MSH, anti-β-LPH, anti-α-endorphin, or anti(1–24)ACTH I.S.
These results indicate that, in man, compound(s) identical with or immunologically related to endorphins, β-LPH, ACTH and MSH are secreted by certain hypothalamic neurons. These agents probably originate from a common precursor molecule similar to the so-called pro-opiocortin.
Immunoreactive fibers terminating around capillaries of the median eminence constitute a tubero-infundibular system that may be involved in the neurohumoral control of the adenohypophysis or in the regulation of other peptidergic or monoaminergic endings. Fibers also terminate close to nonimmunoreactive perikarya that might possibly be dopaminergic.
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