Leptin has emerged over the past decade as a key hormone in not only the regulation of
food intake and energy expenditure but also in the regulation of neuroendocrine and
immune function as well as the modulation of glucose and fat metabolism as shown by
numerous observational and interventional studies in humans with (complete) congenital or
relative leptin deficiency. These results have led to proof-of-concept studies that have
investigated the effect of leptin administration in subjects with complete (congenital) leptin …