Molecular determinants of sodium and water balance during early human development
U Holtbäck, AC Aperia - Seminars in neonatology, 2003 - Elsevier
The past decade has seen enormous progress in understanding the renal regulation of salt
and water homeostasis. Most of the key transporters have been cloned, and their
physiological importance has been revealed from studies of children with inherited diseases
and from mutagenesis studies on a cellular level. We are beginning to understand the
complexity with which the activity of these transporters is regulated by hormones. Studies on
experimental animals have uniformly shown that the majority of renal salt and water …
and water homeostasis. Most of the key transporters have been cloned, and their
physiological importance has been revealed from studies of children with inherited diseases
and from mutagenesis studies on a cellular level. We are beginning to understand the
complexity with which the activity of these transporters is regulated by hormones. Studies on
experimental animals have uniformly shown that the majority of renal salt and water …