[HTML][HTML] Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription
Insulin and insulin-like growth factor-1 (IGF-1) act on highly homologous receptors, yet in
vivo elicit distinct effects on metabolism and growth. To investigate how the insulin and IGF-1
receptors exert specificity in their biological responses, we assessed their role in the
regulation of gene expression using three experimental paradigms: 1) preadipocytes before
and after differentiation into adipocytes that express both receptors, but at different ratios; 2)
insulin receptor (IR) or IGF1R knock-out preadipocytes that only express the complimentary …
vivo elicit distinct effects on metabolism and growth. To investigate how the insulin and IGF-1
receptors exert specificity in their biological responses, we assessed their role in the
regulation of gene expression using three experimental paradigms: 1) preadipocytes before
and after differentiation into adipocytes that express both receptors, but at different ratios; 2)
insulin receptor (IR) or IGF1R knock-out preadipocytes that only express the complimentary …