[HTML][HTML] The JNK signaling pathway in inflammatory skin disorders and cancer
MB Hammouda, AE Ford, Y Liu, JY Zhang - Cells, 2020 - mdpi.com
MB Hammouda, AE Ford, Y Liu, JY Zhang
Cells, 2020•mdpi.comThe c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a
subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide
range of cellular processes, including cell proliferation, differentiation, survival, apoptosis,
and inflammation. Dysregulation of JNK pathway is associated with a wide range of immune
disorders and cancer. Our objective is to provide a review of JNK proteins and their
upstream regulators and downstream effector molecules in common skin disorders …
subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide
range of cellular processes, including cell proliferation, differentiation, survival, apoptosis,
and inflammation. Dysregulation of JNK pathway is associated with a wide range of immune
disorders and cancer. Our objective is to provide a review of JNK proteins and their
upstream regulators and downstream effector molecules in common skin disorders …
The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival, apoptosis, and inflammation. Dysregulation of JNK pathway is associated with a wide range of immune disorders and cancer. Our objective is to provide a review of JNK proteins and their upstream regulators and downstream effector molecules in common skin disorders, including psoriasis, dermal fibrosis, scleroderma, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma.
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