Insulin is expressed by enteroendocrine cells during human fetal development
A Egozi, D Llivichuzhca-Loja, BT McCourt… - Nature medicine, 2021 - nature.com
A Egozi, D Llivichuzhca-Loja, BT McCourt, K Bahar Halpern, L Farack, X An, F Wang…
Nature medicine, 2021•nature.comGeneration of beta cells via transdifferentiation of other cell types is a promising avenue for
the treatment of diabetes. Here we reconstruct a single-cell atlas of the human fetal and
neonatal small intestine. We identify a subset of fetal enteroendocrine K/L cells that express
high levels of insulin and other beta cell genes. Our findings highlight a potential extra-
pancreatic source of beta cells and expose its molecular blueprint.
the treatment of diabetes. Here we reconstruct a single-cell atlas of the human fetal and
neonatal small intestine. We identify a subset of fetal enteroendocrine K/L cells that express
high levels of insulin and other beta cell genes. Our findings highlight a potential extra-
pancreatic source of beta cells and expose its molecular blueprint.
Abstract
Generation of beta cells via transdifferentiation of other cell types is a promising avenue for the treatment of diabetes. Here we reconstruct a single-cell atlas of the human fetal and neonatal small intestine. We identify a subset of fetal enteroendocrine K/L cells that express high levels of insulin and other beta cell genes. Our findings highlight a potential extra-pancreatic source of beta cells and expose its molecular blueprint.
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