Reprogramming cells to make insulin
WM McKimpson, D Accili - Journal of the Endocrine Society, 2019 - academic.oup.com
WM McKimpson, D Accili
Journal of the Endocrine Society, 2019•academic.oup.comType 1 diabetes is a disease characterized by the destruction of insulin-secreting β-cells in
the pancreas. Individuals are treated for this disease with lifelong insulin replacement.
However, one attractive treatment possibility is to reprogram an individual's endogenous
cells to acquire the ability to secrete insulin, essentially replacing destroyed β-cells. Herein,
we review the literature on the topic of reprogramming endodermal cells to produce insulin.
the pancreas. Individuals are treated for this disease with lifelong insulin replacement.
However, one attractive treatment possibility is to reprogram an individual's endogenous
cells to acquire the ability to secrete insulin, essentially replacing destroyed β-cells. Herein,
we review the literature on the topic of reprogramming endodermal cells to produce insulin.
Abstract
Type 1 diabetes is a disease characterized by the destruction of insulin-secreting β-cells in the pancreas. Individuals are treated for this disease with lifelong insulin replacement. However, one attractive treatment possibility is to reprogram an individual’s endogenous cells to acquire the ability to secrete insulin, essentially replacing destroyed β-cells. Herein, we review the literature on the topic of reprogramming endodermal cells to produce insulin.
Oxford University Press