[HTML][HTML] Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane
AJ Johnston, J Hoogenraad, DA Dougan… - Journal of Biological …, 2002 - ASBMB
Tom7 is a component of the translocase of the outer mitochondrial membrane (TOM) and
assembles into a general import pore complex that translocates preproteins into
mitochondria. We have identified the human Tom7 homolog and characterized its import
and assembly into the mammalian TOM complex. Tom7 is imported into mitochondria in a
nucleotide-independent manner and is anchored to the outer membrane with its C terminus
facing the intermembrane space. Unlike studies in fungi, we found that human Tom7 …
assembles into a general import pore complex that translocates preproteins into
mitochondria. We have identified the human Tom7 homolog and characterized its import
and assembly into the mammalian TOM complex. Tom7 is imported into mitochondria in a
nucleotide-independent manner and is anchored to the outer membrane with its C terminus
facing the intermembrane space. Unlike studies in fungi, we found that human Tom7 …