[HTML][HTML] A p300 protein as a coactivator of GATA-6 in the transcription of the smooth muscle-myosin heavy chain gene
H Wada, K Hasegawa, T Morimoto, T Kakita… - Journal of Biological …, 2000 - ASBMB
The mechanisms that regulate smooth muscle development and differentiation are poorly
understood. Although recent studies have suggested the possible role of a zinc finger
transcription factor, GATA-6, in the differentiation of vascular smooth muscle cells (VSMCs),
the downstream gene targeted by GATA-6 is unknown. The expression of smooth muscle-
myosin heavy chain (Sm-MHC) provides a highly specific marker for the differentiated
phenotype of VSMCs as well as the smooth muscle cell lineage. Here, we show that GATA-6 …
understood. Although recent studies have suggested the possible role of a zinc finger
transcription factor, GATA-6, in the differentiation of vascular smooth muscle cells (VSMCs),
the downstream gene targeted by GATA-6 is unknown. The expression of smooth muscle-
myosin heavy chain (Sm-MHC) provides a highly specific marker for the differentiated
phenotype of VSMCs as well as the smooth muscle cell lineage. Here, we show that GATA-6 …
