[HTML][HTML] Metabolic reprograming of anti-tumor immunity
M Sukumar, RJ Kishton, NP Restifo - Current opinion in immunology, 2017 - Elsevier
M Sukumar, RJ Kishton, NP Restifo
Current opinion in immunology, 2017•ElsevierHighlights•Memory T cells have quiescent metabolism.•Activation of T cells triggers both
glycolysis and oxidative phosphorylation.•Elevated T cell metabolic activity is necessary at
the tumor site to promote tumor killing.•High mitochondrial membrane potential (ΔΨm) is
associated with cytokine production and capacity for cytotoxic function.•Metabolic
reprogramming of T cells may improve TCR and chimeric antigen receptor (CAR) based
immunotherapy.Immunotherapies designed to trigger T cell destruction of tumor cells can …
glycolysis and oxidative phosphorylation.•Elevated T cell metabolic activity is necessary at
the tumor site to promote tumor killing.•High mitochondrial membrane potential (ΔΨm) is
associated with cytokine production and capacity for cytotoxic function.•Metabolic
reprogramming of T cells may improve TCR and chimeric antigen receptor (CAR) based
immunotherapy.Immunotherapies designed to trigger T cell destruction of tumor cells can …
Highlights
- Memory T cells have quiescent metabolism.
- Activation of T cells triggers both glycolysis and oxidative phosphorylation.
- Elevated T cell metabolic activity is necessary at the tumor site to promote tumor killing.
- High mitochondrial membrane potential (ΔΨm) is associated with cytokine production and capacity for cytotoxic function.
- Metabolic reprogramming of T cells may improve TCR and chimeric antigen receptor (CAR) based immunotherapy.
Immunotherapies designed to trigger T cell destruction of tumor cells can result in sustained and complete responses in patients whose cancers were resistant to available treatment options. Evidence suggests that powering the T cell response–how T cells generate energy–plays an important role in their effectiveness. Furthermore the metabolism of T cells can be modulated to improve their anti-cancer activities. In this review, we will discuss the key metabolic properties of anti-cancer T cells, along with potential strategies to enhance immunotherapy through the modulation of T cell metabolism.
Elsevier