PT‐141: A melanocortin agonist for the treatment of sexual dysfunction
PB Molinoff, AM Shadiack, D Earle… - Annals of the New …, 2003 - Wiley Online Library
PB Molinoff, AM Shadiack, D Earle, LE Diamond, CY Quon
Annals of the New York Academy of Sciences, 2003•Wiley Online LibraryPT‐141, a synthetic peptide analogue of α‐MSH, is an agonist at melanocortin receptors
including the MC3R and MC4R, which are expressed primarily in the central nervous
system. Administration of PT‐141 to rats and nonhuman primates results in penile erections.
Systemic administration of PT‐141 to rats activates neurons in the hypothalamus as shown
by an increase in c‐Fos immunoreactivity. Neurons in the same region of the central nervous
system take up pseudorabies virus injected into the corpus cavernosum of the rat penis …
including the MC3R and MC4R, which are expressed primarily in the central nervous
system. Administration of PT‐141 to rats and nonhuman primates results in penile erections.
Systemic administration of PT‐141 to rats activates neurons in the hypothalamus as shown
by an increase in c‐Fos immunoreactivity. Neurons in the same region of the central nervous
system take up pseudorabies virus injected into the corpus cavernosum of the rat penis …
Abstract: PT‐141, a synthetic peptide analogue of α‐MSH, is an agonist at melanocortin receptors including the MC3R and MC4R, which are expressed primarily in the central nervous system. Administration of PT‐141 to rats and nonhuman primates results in penile erections. Systemic administration of PT‐141 to rats activates neurons in the hypothalamus as shown by an increase in c‐Fos immunoreactivity. Neurons in the same region of the central nervous system take up pseudorabies virus injected into the corpus cavernosum of the rat penis. Administration of PT‐141 to normal men and to patients with erectile dysfunction resulted in a rapid dose‐dependent increase in erectile activity. The results suggest that PT‐141 holds promise as a new treatment for sexual dysfunction.
Wiley Online Library