Aging has been reported to be accompanied by reduced mitochondrial function and insulin
sensitivity. Whether these deleterious effects result from chronological age or lifestyle-
related factors such as adiposity and physical inactivity remains debatable. The beneficial
effects of exercise on mitochondrial function and insulin sensitivity are well documented;
however, it is unclear whether exercise can effectively prevent, reverse, or delay the onset of
these age-related dysfunctions. Other investigators and we have found that endurance …