Hemoglobin. A biologic fenton reagent.
SM Sadrzadeh, E Graf, SS Panter, PE Hallaway… - Journal of Biological …, 1984 - ASBMB
Iron and iron compounds may facilitate hydroxyl-radical generation from activated oxygen
species. Earlier work on the generation of this radical has been focused on simple, low-
molecular-weight iron compounds. We hypothesized that free hemoglobin, like other iron-
rich substances, might also mediate hydroxyl-radical generation. We find: 1) In the presence
of a superoxide anion-generating system (hypoxanthine and xanthine oxidase), hemoglobin
promotes hydroxyl-radical formation in a dose-dependent fashion. 2) This generation of …
species. Earlier work on the generation of this radical has been focused on simple, low-
molecular-weight iron compounds. We hypothesized that free hemoglobin, like other iron-
rich substances, might also mediate hydroxyl-radical generation. We find: 1) In the presence
of a superoxide anion-generating system (hypoxanthine and xanthine oxidase), hemoglobin
promotes hydroxyl-radical formation in a dose-dependent fashion. 2) This generation of …