[HTML][HTML] Fish oil and fenofibrate prevented phosphorylation-dependent hepatic sortilin 1 degradation in Western diet-fed mice
J Li, L Bi, M Hulke, T Li - Journal of Biological Chemistry, 2014 - ASBMB
Obesity and diabetes are associated with hepatic triglyceride overproduction and
hypertriglyceridemia. Recent studies have found that the cellular trafficking receptor sortilin 1
(Sort1) inhibits hepatic apolipoprotein B secretion and reduces plasma lipid levels in mice,
and its hepatic expression was negatively associated with plasma lipids in humans. This
study investigated the regulation of hepatic Sort1 under diabetic conditions and by lipid-
lowering fish oil and fenofibrate. Results showed that hepatic Sort1 protein, but not mRNA …
hypertriglyceridemia. Recent studies have found that the cellular trafficking receptor sortilin 1
(Sort1) inhibits hepatic apolipoprotein B secretion and reduces plasma lipid levels in mice,
and its hepatic expression was negatively associated with plasma lipids in humans. This
study investigated the regulation of hepatic Sort1 under diabetic conditions and by lipid-
lowering fish oil and fenofibrate. Results showed that hepatic Sort1 protein, but not mRNA …
