Structural and functional connectivity methods are changing how researchers conceptualize
and explore neuropsychiatric disease. Here, we summarize emerging evidence of large-
scale network dysfunction in Alzheimer's disease and behavioral variant frontotemporal
dementia, focusing on the divergent impact these disorders have on the default mode
network and the salience network. We update a working model for understanding the
functions of these networks within a broader anatomical context and highlight the relevance …