[HTML][HTML] Effect of replacing race with apolipoprotein L1 genotype in calculation of kidney donor risk index
BA Julian, RS Gaston, WM Brown… - American Journal of …, 2017 - Elsevier
Renal allografts from deceased African American donors with two apolipoprotein L1 gene
(APOL1) renal-risk variants fail sooner than kidneys from donors with fewer variants. The
Kidney Donor Risk Index (KDRI) was developed to evaluate organ offers by predicting
allograft longevity and includes African American race as a risk factor. Substituting APOL1
genotype for race may refine the KDRI. For 622 deceased African American kidney donors,
we applied a 10-fold cross-validation approach to estimate contribution of APOL1 variants to …
(APOL1) renal-risk variants fail sooner than kidneys from donors with fewer variants. The
Kidney Donor Risk Index (KDRI) was developed to evaluate organ offers by predicting
allograft longevity and includes African American race as a risk factor. Substituting APOL1
genotype for race may refine the KDRI. For 622 deceased African American kidney donors,
we applied a 10-fold cross-validation approach to estimate contribution of APOL1 variants to …