Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells
ELM Guimarães, C Empsen, A Geerts… - Journal of …, 2010 - Elsevier
BACKGROUND AND AIMS: Advanced glycation end products are known to play an
important role in the metabolic syndrome and were recently suggested to contribute to liver
fibrosis development. However, little is known about the effect of advanced glycation end
products on hepatic stellate cells, the major contributors to liver fibrosis development. We
therefore studied the effect of advanced glycation end products on reactive oxygen species
generation, a main feature for the activation hepatic stellate cells. METHODS: Three different …
important role in the metabolic syndrome and were recently suggested to contribute to liver
fibrosis development. However, little is known about the effect of advanced glycation end
products on hepatic stellate cells, the major contributors to liver fibrosis development. We
therefore studied the effect of advanced glycation end products on reactive oxygen species
generation, a main feature for the activation hepatic stellate cells. METHODS: Three different …
