CD4+ T cell migration into the cornea is reduced in CXCL9 deficient but not CXCL10 deficient mice following herpes simplex virus type 1 infection
T Wuest, J Farber, A Luster, DJJ Carr - Cellular immunology, 2006 - Elsevier
The role of CXCL9 and CXCL10 in the ocular immune response to herpes simplex virus type
1 (HSV-1) infection was investigated using mice deficient in either CXCL9 or CXCL10.
CXCL10 but not CXCL9 deficient mice showed an increase in sensitivity to ocular virus
infection as measured by an elevation in virus titer recovered in the tear film and corneal
tissue. The increase in virus was associated with an increase in the expression of the
chemokine CCL2 but no significant change in the infiltration of CD4+ T cells or NK cells into …
1 (HSV-1) infection was investigated using mice deficient in either CXCL9 or CXCL10.
CXCL10 but not CXCL9 deficient mice showed an increase in sensitivity to ocular virus
infection as measured by an elevation in virus titer recovered in the tear film and corneal
tissue. The increase in virus was associated with an increase in the expression of the
chemokine CCL2 but no significant change in the infiltration of CD4+ T cells or NK cells into …
