[HTML][HTML] Sulfatases and a radical S-adenosyl-L-methionine (AdoMet) enzyme are key for mucosal foraging and fitness of the prominent human gut symbiont …
A Benjdia, EC Martens, JI Gordon, O Berteau - Journal of Biological …, 2011 - ASBMB
The large-scale application of genomic and metagenomic sequencing technologies has
yielded a number of insights about the metabolic potential of symbiotic human gut microbes.
Nevertheless, the molecular basis of the interactions between commensal bacteria and their
host remained to be investigated. Bacteria colonizing the mucosal layer that overlies the gut
epithelium are exposed to highly sulfated glycans (ie mucin and glycosaminoglycans).
These polymers can serve as potential nutrient sources, but their high sulfate content usually …
yielded a number of insights about the metabolic potential of symbiotic human gut microbes.
Nevertheless, the molecular basis of the interactions between commensal bacteria and their
host remained to be investigated. Bacteria colonizing the mucosal layer that overlies the gut
epithelium are exposed to highly sulfated glycans (ie mucin and glycosaminoglycans).
These polymers can serve as potential nutrient sources, but their high sulfate content usually …