The contribution of regulatory T cells in the maintenance of kidney graft survival is of major
interest. Although many experimental models suggest a role in the induction of graft
tolerance, reproducing these findings in clinic is less clear. While modulation of the
regulatory T cell response is a promising therapeutic concept in transplantation, a better
understanding of function, phenotype and biology is needed to be able to optimally exploit
these cells in order to induce graft tolerance. With this in mind, we review here the current …