Adverse outcomes of tacrolimus withdrawal in immune–quiescent kidney transplant recipients
DE Hricik, RN Formica, P Nickerson… - Journal of the …, 2015 - journals.lww.com
Concerns about adverse effects of calcineurin inhibitors (CNIs) have prompted development
of protocols that minimize their use. Whereas previous CNI withdrawal trials in
heterogeneous cohorts showed unacceptable rates of acute rejection (AR), we
hypothesized that we could identify individuals capable of tolerating CNI withdrawal by
targeting immunologically quiescent kidney transplant recipients. The Clinical Trials in
Organ Transplantation-09 Trial was a randomized, prospective study of nonsensitized …
of protocols that minimize their use. Whereas previous CNI withdrawal trials in
heterogeneous cohorts showed unacceptable rates of acute rejection (AR), we
hypothesized that we could identify individuals capable of tolerating CNI withdrawal by
targeting immunologically quiescent kidney transplant recipients. The Clinical Trials in
Organ Transplantation-09 Trial was a randomized, prospective study of nonsensitized …