Minimally modified low density lipoprotein (mmLDL) is a pro-inflammatory and pro-
atherogenic lipoprotein that, unlike profoundly oxidized LDL (OxLDL), is not recognized by
scavenger receptors and thus does not have enhanced uptake by macrophages. However,
here we demonstrate that mmLDL (as well as OxLDL) induces actin polymerization and
spreading of macrophages, which results in such pro-atherogenic consequences as
inhibition of phagocytosis of apoptotic cells but enhancement of OxLDL uptake. We also …