[HTML][HTML] Endoproteolytic cleavage of TUG protein regulates GLUT4 glucose transporter translocation
JS Bogan, BR Rubin, C Yu, MG Löffler… - Journal of Biological …, 2012 - ASBMB
To promote glucose uptake into fat and muscle cells, insulin causes the translocation of
GLUT4 glucose transporters from intracellular vesicles to the cell surface. Previous data
support a model in which TUG traps GLUT4-containing vesicles and tethers them
intracellularly in unstimulated cells and in which insulin mobilizes this pool of vesicles by
releasing this tether. Here we show that TUG undergoes site-specific endoproteolytic
cleavage, which separates a GLUT4-binding, N-terminal region of TUG from a C-terminal …
GLUT4 glucose transporters from intracellular vesicles to the cell surface. Previous data
support a model in which TUG traps GLUT4-containing vesicles and tethers them
intracellularly in unstimulated cells and in which insulin mobilizes this pool of vesicles by
releasing this tether. Here we show that TUG undergoes site-specific endoproteolytic
cleavage, which separates a GLUT4-binding, N-terminal region of TUG from a C-terminal …