Signal transducer and activator of transcription 3 (STAT3) protein suppresses adenoma-to-carcinoma transition in Apcmin/+ mice via regulation of Snail-1 (SNAI) …
J Lee, JCK Kim, SE Lee, C Quinley, HR Kim… - Journal of Biological …, 2012 - ASBMB
STAT3 was recently reported to suppress tumor invasion in Apc min/+ mice. We investigated
the mechanisms by which STAT3 inhibits intestinal epithelial tumors using Apc min/+/Stat3
IEC-KO mice (intestinal epithelial cell (IEC)-specific deletion of STAT3 in the Apc min/+
background) to determine the role of STAT3 in carcinogenesis in vivo as well as colorectal
cancer cell lines in vitro. To inhibit invasion of IEC tumors, STAT3 functions as a molecular
adaptor rather than a transcription factor. Accordingly, the tumors in Apc min/+/Stat3 IEC-KO …
the mechanisms by which STAT3 inhibits intestinal epithelial tumors using Apc min/+/Stat3
IEC-KO mice (intestinal epithelial cell (IEC)-specific deletion of STAT3 in the Apc min/+
background) to determine the role of STAT3 in carcinogenesis in vivo as well as colorectal
cancer cell lines in vitro. To inhibit invasion of IEC tumors, STAT3 functions as a molecular
adaptor rather than a transcription factor. Accordingly, the tumors in Apc min/+/Stat3 IEC-KO …
