Interaction of activated platelets and leukocytes (mainly neutrophils) on the activated
endothelium mediates thrombosis and vascular inflammation. 1, 2 During thrombus
formation at the site of arteriolar injury, platelets adherent to the activated endothelium and
subendothelial matrix proteins support neutrophil rolling and adhesion. 3 Conversely, under
venular inflammatory conditions, neutrophils adherent to the activated endothelium can
support adhesion and accumulation of circulating platelets. Heterotypic platelet-neutrophil …