[HTML][HTML] SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity
TH Barker, G Baneyx, M Cardó-Vila… - Journal of Biological …, 2005 - ASBMB
SPARC, a 32-kDa matricellular glycoprotein, mediates interactions between cells and their
extracellular matrix, and targeted deletion of Sparc results in compromised extracellular
matrix in mice. Fibronectin matrix provides provisional tissue scaffolding during development
and wound healing and is essential for the stabilization of mature extracellular matrix.
Herein, we report that SPARC expression does not significantly affect fibronectin-induced
cell spreading but enhances fibronectin-induced stress fiber formation and cell-mediated …
extracellular matrix, and targeted deletion of Sparc results in compromised extracellular
matrix in mice. Fibronectin matrix provides provisional tissue scaffolding during development
and wound healing and is essential for the stabilization of mature extracellular matrix.
Herein, we report that SPARC expression does not significantly affect fibronectin-induced
cell spreading but enhances fibronectin-induced stress fiber formation and cell-mediated …