Bisphosphonate therapy for osteogenesis imperfecta
CA Phillipi, T Remmington… - Cochrane Database of …, 2008 - cochranelibrary.com
CA Phillipi, T Remmington, RD Steiner
Cochrane Database of Systematic Reviews, 2008•cochranelibrary.comBackground In osteogenesis imperfecta (OI) a genetic defect in type I collagen results in
multiple fractures with little or no trauma. Bisphosphonates are used to attempt to reduce
these fractures. Objectives To assess the effectiveness and safety of bisphosphonates in
increasing bone mineral density (BMD), reducing fractures and improving clinical function in
people with OI.
multiple fractures with little or no trauma. Bisphosphonates are used to attempt to reduce
these fractures. Objectives To assess the effectiveness and safety of bisphosphonates in
increasing bone mineral density (BMD), reducing fractures and improving clinical function in
people with OI.
Background
In osteogenesis imperfecta (OI) a genetic defect in type I collagen results in multiple fractures with little or no trauma. Bisphosphonates are used to attempt to reduce these fractures.
Objectives
To assess the effectiveness and safety of bisphosphonates in increasing bone mineral density (BMD), reducing fractures and improving clinical function in people with OI.
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