[HTML][HTML] Behavior of CD34+ cells isolated from patients with polycythemia vera in NOD/SCID mice
T Ishii, Y Zhao, S Sozer, J Shi, W Zhang… - Experimental …, 2007 - Elsevier
OBJECTIVE: We investigated if polycythemia vera (PV) peripheral blood (PB) CD34+ cells
contain cells capable of engrafting nonobese diabetic/severe combined immunodeficient
(NOD/SCID) mice and if the JAK2V617F mutational burden of these cells alters their
behavior in NOD/SCID mice. MATERIALS AND METHODS: CD34+ cells isolated from
patients with PV, idiopathic myelofibrosis (IM), or granulocyte colony-stimulating factor–
mobilized normal donors were transplanted into sublethally irradiated NOD/SCID mice …
contain cells capable of engrafting nonobese diabetic/severe combined immunodeficient
(NOD/SCID) mice and if the JAK2V617F mutational burden of these cells alters their
behavior in NOD/SCID mice. MATERIALS AND METHODS: CD34+ cells isolated from
patients with PV, idiopathic myelofibrosis (IM), or granulocyte colony-stimulating factor–
mobilized normal donors were transplanted into sublethally irradiated NOD/SCID mice …