Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders
R Kralovics, RC Skoda - Blood reviews, 2005 - Elsevier
We summarize the current knowledge on molecular alterations in myeloproliferative
disorders (MPD), in particular altered in vitro responses of progenitor cells, cytokine
signaling, gene expression patterns and genetic lesions. Newly characterized markers, such
as altered expression of polycythemia rubra vera-1 (PRV-1) and the thrombopoietin receptor
(c-MPL) as well as deletions on chromosome 20q (del20q) and loss of heterozygosity on
chromosome 9p (9pLOH) provide an opportunity to diagnose and identify subpopulations of …
disorders (MPD), in particular altered in vitro responses of progenitor cells, cytokine
signaling, gene expression patterns and genetic lesions. Newly characterized markers, such
as altered expression of polycythemia rubra vera-1 (PRV-1) and the thrombopoietin receptor
(c-MPL) as well as deletions on chromosome 20q (del20q) and loss of heterozygosity on
chromosome 9p (9pLOH) provide an opportunity to diagnose and identify subpopulations of …