Uptake and localisation of O-(β-hydroxyethyl)-rutosides in the venous wall, measured by laser scanning microscopy
HAM Neumann, K Carlsson, GHM Brom - European journal of clinical …, 1992 - Springer
HAM Neumann, K Carlsson, GHM Brom
European journal of clinical pharmacology, 1992•SpringerThe uptake and localisation of O-(β-hy-droxyethyl)-rutosides (HR) in the venous wall was
studied in 8 patients undergoing crossectomy for a varicose long saphenous vein. The
fluorescence of cross-sections of the vein wall was measured by laser scanning microscopy,
based on the autofluorescence of HR. Four patients (treated group) received 2× 1.5 g HR IV
before surgery, and four (untreated patients) served as controls. Uptake of HR into the veins
from treated patients was seen, with a mean fluorescence intensity of 80.9 units compared to …
studied in 8 patients undergoing crossectomy for a varicose long saphenous vein. The
fluorescence of cross-sections of the vein wall was measured by laser scanning microscopy,
based on the autofluorescence of HR. Four patients (treated group) received 2× 1.5 g HR IV
before surgery, and four (untreated patients) served as controls. Uptake of HR into the veins
from treated patients was seen, with a mean fluorescence intensity of 80.9 units compared to …
Summary
The uptake and localisation of O-(β-hy-droxyethyl)-rutosides (HR) in the venous wall was studied in 8 patients undergoing crossectomy for a varicose long saphenous vein. The fluorescence of cross-sections of the vein wall was measured by laser scanning microscopy, based on the autofluorescence of HR. Four patients (treated group) received 2 × 1.5 g HR IV before surgery, and four (untreated patients) served as controls.
Uptake of HR into the veins from treated patients was seen, with a mean fluorescence intensity of 80.9 units compared to 49.4 units in the untreated veins. The increase in fluorescence was clearly demarcated on the endothelial side of the vein wall.
It is concluded that HR passes into the vascular wall, where it is localised in the endothelial and sub-endothelial areas.
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