Exposure of the cryptic Arg-Gly-Asp sequence in thrombospondin-1 by protein disulfide isomerase
KA Hotchkiss, LJ Matthias, PJ Hogg - Biochimica et Biophysica Acta (BBA) …, 1998 - Elsevier
Thrombospondin-1 is a matrix protein that inhibits proliferation, motility and sprouting of
endothelial cells in vitro and angiogenesis in vivo. One mechanism by which
thrombospondin-1 may influence endothelial cell biology is through interaction with the
endothelial cell αvβ3 integrin receptor. This interaction is mediated via a cryptic Arg-Gly-Asp
sequence in the C-terminal Ca2+-binding region of thrombospondin-1. Exposure of the Arg-
Gly-Asp sequence is controlled by disulfide interchange events in the Ca2+-binding loops …
endothelial cells in vitro and angiogenesis in vivo. One mechanism by which
thrombospondin-1 may influence endothelial cell biology is through interaction with the
endothelial cell αvβ3 integrin receptor. This interaction is mediated via a cryptic Arg-Gly-Asp
sequence in the C-terminal Ca2+-binding region of thrombospondin-1. Exposure of the Arg-
Gly-Asp sequence is controlled by disulfide interchange events in the Ca2+-binding loops …