[HTML][HTML] Distinct roles of glycogen synthase kinase (GSK)-3α and GSK-3β in mediating cardiomyocyte differentiation in murine bone marrow-derived mesenchymal …
J Cho, P Rameshwar, J Sadoshima - Journal of Biological Chemistry, 2009 - ASBMB
The signaling mechanisms facilitating cardiomyocyte (CM) differentiation from bone marrow
(BM)-derived mesenchymal stem cells (MSCs) are not well understood. 5-Azacytidine (5-
Aza), a DNA demethylating agent, induces expression of cardiac-specific genes, such as
Nkx2. 5 and α-MHC, in mouse BM-derived MSCs. 5-Aza treatment caused significant up-
regulation of glycogen synthase kinase (GSK)-3β and down-regulation of β-catenin,
whereas it stimulated GSK-3α expression only modestly. The promoter region of GSK-3β …
(BM)-derived mesenchymal stem cells (MSCs) are not well understood. 5-Azacytidine (5-
Aza), a DNA demethylating agent, induces expression of cardiac-specific genes, such as
Nkx2. 5 and α-MHC, in mouse BM-derived MSCs. 5-Aza treatment caused significant up-
regulation of glycogen synthase kinase (GSK)-3β and down-regulation of β-catenin,
whereas it stimulated GSK-3α expression only modestly. The promoter region of GSK-3β …