[HTML][HTML] Glycogen synthase kinase− 3β inhibitors suppress leukemia cell growth
EY Song, P Palladinetti, G Klamer, KH Ko… - Experimental …, 2010 - Elsevier
OBJECTIVE: The objective of this study was to investigate the effect of small molecule
inhibitors of glycogen synthase kinase− 3β (GSK-3β) on leukemia cell growth and survival.
MATERIALS AND METHODS: Analysis of cytotoxicity and cell proliferation was conducted
using the MTS assay, cell-cycle analysis, and division tracking. Apoptosis was investigated
by Annexin-V/7-aminoactinomycin D and caspase-3 expression. The effect of GSK-3β
inhibitors was also tested in vivo in an animal model of leukemia. Gene expression analysis …
inhibitors of glycogen synthase kinase− 3β (GSK-3β) on leukemia cell growth and survival.
MATERIALS AND METHODS: Analysis of cytotoxicity and cell proliferation was conducted
using the MTS assay, cell-cycle analysis, and division tracking. Apoptosis was investigated
by Annexin-V/7-aminoactinomycin D and caspase-3 expression. The effect of GSK-3β
inhibitors was also tested in vivo in an animal model of leukemia. Gene expression analysis …