Rethinking how DNA methylation patterns are maintained
DNA methylation patterns are set up early in mammalian development and are then copied
during the division of somatic cells. A long-established model for the maintenance of these
patterns explains some, but not all, of the data that are now available. We propose a new
model that suggests that the maintenance of DNA methylation relies not only on the
recognition of hemimethylated DNA by DNA methyltransferase 1 (DNMT1) but also on the
localization of the DNMT3A and DNMT3B enzymes to specific chromatin regions that …
during the division of somatic cells. A long-established model for the maintenance of these
patterns explains some, but not all, of the data that are now available. We propose a new
model that suggests that the maintenance of DNA methylation relies not only on the
recognition of hemimethylated DNA by DNA methyltransferase 1 (DNMT1) but also on the
localization of the DNMT3A and DNMT3B enzymes to specific chromatin regions that …
Abstract
DNA methylation patterns are set up early in mammalian development and are then copied during the division of somatic cells. A long-established model for the maintenance of these patterns explains some, but not all, of the data that are now available. We propose a new model that suggests that the maintenance of DNA methylation relies not only on the recognition of hemimethylated DNA by DNA methyltransferase 1 (DNMT1) but also on the localization of the DNMT3A and DNMT3B enzymes to specific chromatin regions that contain methylated DNA.
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