The term epigenetics defines a heritable alteration in gene expression without an
accompanying change in primary DNA sequence. Two major mechanisms that foster
epigenetic changes are DNA methylation at cytosine bases within a CpG dinucleotide and
post-translational histone modifications. Disruption of the balanced epigenetic network may
have significant impact on chromatin structure and transcriptional activity. DNA methylation
patterns are profoundly deranged in human cancer and comprise genome-wide losses as …