GATA factor switching during erythroid differentiation
H Kaneko, R Shimizu, M Yamamoto - Current opinion in …, 2010 - journals.lww.com
H Kaneko, R Shimizu, M Yamamoto
Current opinion in hematology, 2010•journals.lww.comStrict regulations of the Gata1 and Gata2 genes are critical for proper lineage commitment
and development of erythroid cells. It has been shown in transgenic mouse analyses that cis-
acting GATA binding motifs are critical for the expression of Gata1 and Gata2 genes.
Furthermore, expression of Gata1 and Gata2 genes along with a set of erythroid genes
appeared to be regulated by GATA factor switching.
and development of erythroid cells. It has been shown in transgenic mouse analyses that cis-
acting GATA binding motifs are critical for the expression of Gata1 and Gata2 genes.
Furthermore, expression of Gata1 and Gata2 genes along with a set of erythroid genes
appeared to be regulated by GATA factor switching.
Summary
Strict regulations of the Gata1 and Gata2 genes are critical for proper lineage commitment and development of erythroid cells. It has been shown in transgenic mouse analyses that cis-acting GATA binding motifs are critical for the expression of Gata1 and Gata2 genes. Furthermore, expression of Gata1 and Gata2 genes along with a set of erythroid genes appeared to be regulated by GATA factor switching.
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